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Preserving Muscle Mass on GLP-1 Medications



In recent years, GLP-1 medications have emerged as a powerful tool in the fight against obesity and weight-related health issues. These medications, including well-known options like semaglutide (Ozempic) and liraglutide (Saxenda), as well as FDA-approved compounds, work by mimicking the action of a hormone that regulates appetite and glucose levels. They help patients achieve significant weight loss by reducing hunger and promoting a feeling of fullness. However, as with any weight loss intervention, there are important considerations to keep in mind—one of the most critical being the preservation of muscle mass.

Why Muscle Mass Matters

Muscle mass isn't just about strength or aesthetics; it plays a vital role in overall health. Muscles are metabolically active tissues that help regulate blood sugar levels, support bone health, and maintain mobility. Losing muscle during weight loss can lead to a decrease in metabolic rate, making it harder to sustain weight loss over the long term. Additionally, reduced muscle mass can increase the risk of injury and diminish physical function, especially as we age.

The Challenge with GLP-1 Medications: Does Ozempic Cause Muscle Loss?

While GLP-1 medications like Ozempic can be highly effective for weight loss, there's a potential downside: these medications may lead to a reduction in both fat and muscle mass. This is because rapid weight loss, regardless of the method, often results in the loss of some lean tissue along with fat. Therefore, individuals on any type of GLP-1 medication need to take proactive steps to preserve their muscle mass while still achieving their weight loss goals.

Strategies for Preserving Muscle Mass

Incorporate Resistance Training

Engaging in regular resistance training, such as weight lifting or bodyweight exercises, is one of the most effective ways to preserve muscle mass. Aim for at least two to three sessions per week, focusing on all major muscle groups. Resistance training helps stimulate muscle protein synthesis, counteracting the muscle loss that can occur during weight loss.

Prioritize Protein Intake

Adequate protein intake is essential for muscle preservation. As you lose weight, your body may require more protein to maintain muscle mass. Aim for a protein intake of about 1.2 to 1.6 grams per kilogram of body weight per day, depending on your activity level. Include high-quality protein sources such as lean meats, fish, eggs, dairy, legumes, and plant-based proteins in your diet.

Monitor Nutritional Intake

While GLP-1 medications help reduce calorie intake, it's important to ensure you're still consuming enough nutrients to support muscle health. Consider working with a functional medicine practitioner or a registered dietitian to develop a balanced eating plan that meets your individual needs. This plan should include a variety of nutrient-dense foods to provide essential vitamins and minerals.

Stay Active with Cardiovascular Exercise

While resistance training is crucial, cardiovascular exercise also plays a role in overall health and weight management. Activities like walking, swimming, or cycling can help improve cardiovascular fitness without contributing to significant muscle loss. Incorporating a mix of moderate-intensity aerobic exercise with resistance training will provide a well-rounded approach to preserving muscle mass.

Consider Nutritional Supplements

In some cases, nutritional supplements may be beneficial for preserving muscle mass. Supplements such as branched-chain amino acids (BCAAs), creatine, and omega-3 fatty acids have been shown to support muscle health during weight loss. However, it's essential to consult with a healthcare provider before starting any new supplement regimen.

Lose Weight the Healthy Way with The Johnson Center

At The Johnson Center, we take a holistic approach to weight management. We understand that every individual is unique, and our goal is to help you achieve sustainable weight loss while maintaining optimal health. By incorporating these strategies and working closely with our team, you can preserve muscle mass while benefiting from the weight loss effects of the GLP-1 compound medications that we offer.


If you're considering a weight loss program or are currently taking GLP-1 medications, we invite you to learn more about our program and schedule a consultation with our team. Together, we can create a personalized plan that aligns with your goals and supports your long-term health and well-being.


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